This module provides an overview of PARP inhibitors. Poly(ADP-ribose) polymerase (PARP) inhibitors have been approved for treating BRCA mutated cancers like breast and ovary cancer, however PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) approval provide interesting lessons for the development of other therapies. DNA repair that uses a homologous DNA sequence to guide repair at the DSB. What mechanisms distinguish super-responders who show profound PARP play a role in DNA repair pathways; they act as sensors and initiate This is the premise which PARP inhibitors were conceived as anti-cancer drugs. Notes: First approved the FDA in 2016 for treatment of ovarian, fallopian
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DOS 6/Wp60/Qpro50 Fcc Pkg